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Postdoctoral Associate - Rosen Lab
Howard Hughes Medical Institute (HHMI) | |
relocation assistance | |
United States, Massachusetts, Boston | |
4 Blackfan Circle (Show on map) | |
April 23, 2024 | |
Primary Work Address: 6001 Forest Park Road, Dallas, TX, 75390-9050
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About the role:
A postdoctoral training position is available in the laboratory of Dr. , in the and Howard Hughes Medical Institute at UT Southwestern Medical Center. We seek to recruit individuals who can apply cryoelectron tomography to understand the molecular organization of biomolecular condensates in vitro and in cells. About Department/Lab:Following on our studies of biochemically reconstituted chromatin condensates (Gibson et al., Cell, 2019; Gibson et al., PNAS, 2023), we have developed methods to determine the higher-order organization of polynucleosome arrays in high-pressure frozen, cryoFIB milled samples using cryoET. We now plan to expand this technology to further explore chromatin itself, as well as the structures of various chromatin machines working within condensates. Additionally, we will apply the tools and knowledge to other biomolecular condensates. We will examine both biochemically reconstituted condensates as well as their cellular counterparts, with a goal of relating structural organization to function across a range of length scales (Lyon et al., Nature Reviews Molec Cell Biol, 2021). Members of the Rosen lab have access to outstanding cryoEM facilities at UTSW, including two Titan Krios microscopes, an Aquilos 2 cryoFIB mill, a Stellaris-5 cryo-confocal light microscope and a Leica EM Ice high pressure freezer; as well as cryoEM instrumentation at the Janelia campus of the Howard Hughes Medical Institute. Members also benefit from a deep understanding of condensate biophysics, biochemistry and biology within a leading lab in the field. What we provide:
In addition to the duties specifically identified by this job description, the position will include other duties if and as assigned by the direct supervisor or others with supervisory authority over this position. Scope
Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis. Please Note:This job description sets forth the job's principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word "may," the Essential Duties and Responsibilities described above are "essential functions" of the job, as defined by the Americans with Disabilities Act. Compensation and BenefitsOur employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our site to learn more. HHMI is an Equal Opportunity EmployerCompensation and Benefits Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our site to learn more. Compensation Range $70,000.00 (minimum) - $80,500.00 (midpoint) - $91,000.00 (maximum)Pay Type: AnnualHHMI's salary structure is developed based on relevant job market data. HHMI considers a candidate's education, previous experiences, knowledge, skills and abilities, as well as internal equity when making job offers. Typically, a new hire for this position in this location is compensated between the minimum and the midpoint of the salary range. |