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In Vitro Pharmacology Scientist II

Springworks Therapeutics
$114,330
401(k)
United States, North Carolina, Raleigh
June 28, 2023
About SpringWorks Therapeutics SpringWorks is a clinical-stage biopharmaceutical company applying a precision medicine approach to acquiring, developing and commercializing life-changing medicines for patients living with severe rare diseases and cancer. SpringWorks has a differentiated targeted oncology pipeline spanning solid tumors and hematological cancers, including two late-stage clinical trials in rare tumor types as well as several programs addressing highly prevalent, genetically defined cancers. SpringWorks' strategic approach and operational excellence in clinical development have enabled it to rapidly advance its two lead product candidates into late-stage clinical trials while simultaneously entering into multiple shared-value partnerships with innovators in industry and academia to unlock the full potential for its portfolio and create more solutions for patients with cancer. We give it our all every day because we believe in the power of targeted oncology to help people with cancer. If you recognize yourself in us, then we'd like to meet you. The answers are waiting - and we need your help finding them. About the Role: Reporting to the Director, Discovery Biology, the In Vitro Pharmacology Scientist II will serve as the lead of the In Vitro Pharmacology team, contributing to the development of preclinical biochemical/cellular assays to identify novel small molecule Oncology drug candidates. This role will contribute to building a culture of scientific excellence, rigorous innovation, collaboration, and teamwork in a cross-functional setting. This individual will have prior experience in the pharmaceutical industry and a track record of scientific achievement. This individual will directly or indirectly train or supervise junior staff and may support the activities of CRO partners. This individual will have experience in designing, conducting, and troubleshooting biochemical/cellular assays and studies characterizing the activity of small molecules in tumor biology, in the pharmaceutical/Biotech industry. Responsibilities Include: Design and execution of in vitro pharmacology studies using biochemical and cellular assays for small molecule Oncology programs. Initiate investigation of new experimental in vitro pharmacology approaches to specific problems using data from internal/external partners, and technical literature. Collaborate with project leaders to implement scientific technologies with minimal supervision for Oncology R&D programs. May supervise and train junior staff, ensuring safe and productive laboratory practice. May work as part of a team to develop new intellectual property and co-author patent applications and peer-reviewed publications. Implement new technologies to enhance productivity and efficiency across the Discovery Chemistry, DMPK and Discovery Biology groups. Experience in analyzing, interpreting, and visualizing scientific data. Collaborate with project teams in identifying research approaches, hypotheses to be tested, and program milestones to achieve program objective. Lead preparation of key findings with the possibility of presenting to internal/external stakeholders at scientific meetings and conferences. Model SpringWorks values and exemplify scientific excellence within Discovery Biology. Perform other duties and responsibilities as assigned. About You: Required Education, Skills, and Experience Ph.D. in Molecular and/or Cellular/Tumor Biology plus 5+ years' experience in cellular and biochemical assays in biotech/pharma; ideally, in a drug discovery/development setting., or M.S. in Molecular and/or Cellular/Tumor Biology plus 8+ years' experience in cellular and biochemical assays in biotech/pharma; ideally, in a drug discovery/development setting preferred. Experience in cell/tissue culture, target validation, drug combination-IC50 assays, qPCR assay development, MOA studies for small molecule inhibitors, High content imaging platforms including Luminex, ELISA, ELISPOT assays and Flow Cytometry (FACS). Highly experienced in use of Tecan D300 drug delivery platform, IncuCyte assays, Lentivirus transductions, Fluorescent and confocal microscopy. Knowledge of principles, theories, and practices in molecular and cellular biology. Scientific creativity and productivity in drug discovery/development. Experience in the interpretation, analysis, documentation, and presentation of key findings in internal and external meetings. Ability Effective training, mentoring and professional development of more junior staff. Ability to lead other laboratory scientists by example and informal mentoring. Hands-on supervision of laboratory work and personnel to ensure safe laboratory practices. Effective organizational, interpersonal, communication and managerial skills. Ability to maintain detailed documentation through electronic and notebook means. Excellent written and oral communication skills. Ability to communicate technical and cross-functional data to team members and program leaders. Proven ability to work within a fast-paced environment. This position is lab-based and will be required to be on-site 5 days a week. The expected salary range for this position is $114,330.00 - $150,000.00. Actual pay will be determined based on experience, qualifications, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. We also offer a comprehensive benefits package for our team of SpringWorkers and their families, including competitive compensation, annual cash bonuses and equity grants, 401K matching, fully covered medical, dental, and vision plans, and a full week of holiday break at year end. It's the right thing to do - and helps us be healthy, happy, and at our best for the people who need us. At SpringWorks, we believe in fostering a culture of belonging. Our Employee Resource Group's (ERG) mission is to boldly live the SpringWorks values, provide resources, and deeply engage SpringWorkers and the communities we serve to foster a culture of belonging. Ensuring diversity, equity, and inclusion are integral to our organization's DNA. SpringWorks is an equal employment opportunity employer that is strongly committed to equal employment opportunities for all individuals. The Company does not discriminate in employment opportunities or practices on the basis of actual or perceived sex (including pregnancy, childbirth, breast feeding or related medical conditions), gender, gender identity or gender expression, sexual orientation, partnership status, marital status, familial status, pregnancy status, race, color, national origin, ancestry, religion, religious creed, age, alienage or citizenship status, veteran status, military status, physical or mental disability, past or present history of mental disorder, medical condition, AIDS/HIV status, sickle cell or hemoglobin C trait, genetic predisposition, genetic information, protected medical leaves, domestic violence victim status, sex offense or stalking victim status, political affiliation and any and all other characteristics or categories protected by applicable federal, state or local laws. This Equal Employment Opportunity Policy applies toallaspects of employment, including, without limitation, recruitment, hiring, placement, job assignment, promotion, termination, transfer, leaves of absence, compensation, discipline, and access to benefits and training. Any violation of this Policy will result in disciplinary action up to and including termination of employment. GDPR Statement: When you apply to a job on this site, the personal data contained in your application will be collected by SpringWorks Therapeutics ("Controller"), which is located at 100 Washington Blvd, Stamford CT 6902 and can be contacted by emailing . Your personal data will be processed for the purposes of managing Controller's recruitment related activities, which include setting up and conducting interviews and tests for applicants, evaluating and assessing the results thereto, and as is otherwise needed in the recruitment and hiring processes. 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